Adjunctive Hyperbaric Oxygen Therapy promotes successful healing in patients with refractory Crohn's disease

Acta Cir Bras. 2016:31 Suppl 1:19-23. doi: 10.1590/S0102-86502016001300005.


Purpose: To investigate de adjunctive effect of Hyperbaric Oxygen Therapy in a group of patients with refractory Crohn's disease.

Methods: A total of 29 subjects with refractory Crohn's disease were submitted to daily sessions of Hyperbaric Oxygen Therapy, in a 2800 Sechrist Monoplace Hyperbaric Chamber (Sechrist, USA) pressurized to 2.4 ATA. Each session lasted 2 hours. The endpoint was closure of enterocutaneous fistulas and complete healing of Pyoderma Gangrenosum and perineal Crohn's disease.

Results: A total of 829 HBOT sessions were performed and no complications were noted. Overall success rate was 76% (22 cases). Pyoderma Gangrenosum and enterocutaneous fistulas had the highest successful healing rates (100% and 91%, respectively). Perineal Crohn's disease healing rate was 65%.

Conclusion: Adjunctive Hyperbaric Oxygen Therapy promoted satisfactory healing in a group of patients with refractory Crohn's disease.

MeSH terms

  • Adult
  • Aged
  • Child
  • Combined Modality Therapy
  • Crohn Disease / therapy*
  • Female
  • Humans
  • Hyperbaric Oxygenation / methods*
  • Hyperbaric Oxygenation / statistics & numerical data
  • Intestinal Fistula / therapy*
  • Male
  • Middle Aged
  • Prospective Studies
  • Pyoderma Gangrenosum / therapy*
  • Reproducibility of Results
  • Time Factors
  • Treatment Outcome
  • Wound Healing*
  • Young Adult