Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers

Sci Rep. 2016 May 4;6:25309. doi: 10.1038/srep25309.

Abstract

Least component-based delivery of drug-tagged-nanocarriers across blood-brain-barriers (BBB) will allow site-specific and on-demand release of therapeutics to prevent CNS diseases. We developed a non-invasive magnetically guided delivery of magneto-electric nanocarriers (MENCs), ~20 nm, 10 mg/kg, across BBB in C57Bl/J mice. Delivered MENCs were uniformly distributed inside the brain, and were non-toxic to brain and other major organs, such as kidney, lung, liver, and spleen, and did not affect hepatic, kidney and neurobehavioral functioning.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Central Nervous System / chemistry*
  • Drug Carriers / administration & dosage
  • Drug Carriers / adverse effects*
  • Drug Carriers / pharmacokinetics*
  • Magnetic Fields*
  • Metal Nanoparticles / administration & dosage
  • Metal Nanoparticles / adverse effects*
  • Mice, Inbred C57BL

Substances

  • Drug Carriers