Hyaluronate in healing of corneal alkali wound in the rabbit

Exp Eye Res. 1989 Apr;48(4):569-76. doi: 10.1016/0014-4835(89)90039-0.


The effect of topically applied 1% and 2% sodium hyaluronate was studied on the healing of a standardized rabbit corneal alkali wound. The healing of the epithelium, the stroma, and the endothelium was evaluated separately by applying quantitative methods. The healing was followed for 8 weeks. Both 1% and 2% sodium hyaluronate have a statistically significant positive influence on the epithelial re-surfacing, especially during the late healing phase. Furthermore, sodium hyaluronate has a positive healing influence on the stromal healing at a certain time interval during the observation period. This was reflected as a better maintained stromal dry mass level compared to control. The stromal healing was parallel to a faster re-surfacing of the endothelium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Alkalies
  • Animals
  • Burns, Chemical / drug therapy*
  • Corneal Injuries*
  • Corneal Stroma / drug effects
  • Endothelium, Corneal / drug effects
  • Epithelium / drug effects
  • Eye Burns / chemically induced*
  • Eye Burns / drug therapy
  • Hyaluronic Acid / administration & dosage
  • Hyaluronic Acid / therapeutic use*
  • Rabbits
  • Sodium Hydroxide
  • Wound Healing / drug effects*


  • Alkalies
  • Sodium Hydroxide
  • Hyaluronic Acid