Effects of Prunus mume Sieb. et Zucc. extract and its biopolymer encapsulation on a mouse model of colitis

J Sci Food Agric. 2017 Jan;97(2):686-692. doi: 10.1002/jsfa.7790. Epub 2016 Jun 15.

Abstract

Background: Prunus mume suppresses various diseases caused by inflammation response and exhibits antioxidant and free radical-scavenging activities. Therefore this study determined the effect of an aqueous P. mume (PM) extract in a mouse colitis model and investigated the value of biopolymer encapsulation, facilitating targeted delivery to the colon. Colitis was induced by administration of 30 g kg-1 dextran sulfate sodium to male BALB/c mice for 7 days prior to treatment with vehicle, 50 mg kg-1 PM extract or biopolymer-encapsulated PM extract, or 50 mg kg-1 sulfasalazine.

Results: Histological examination of the colon in BALB/c mice showed epithelial destruction and mucosal infiltration of inflammatory cells. These changes were attenuated in PM-treated mice, which had lower levels of inflammatory cytokines, cyclooxygenase 2 and immunoglobulins (IgA, IgM and IgE) compared with the vehicle-treated colitis group. The PM extract showed concentration-dependent radical scavenging and superoxide dismutase-like antioxidant activities.

Conclusion: These results indicated that the effects of the PM extract on colitis were not influenced by biopolymer encapsulation and that this PM extract could be a potential therapeutic agent for inflammatory bowel disease. © 2016 Society of Chemical Industry.

Keywords: Prunus mume; anti-inflammatory; antioxidant; biopolymer encapsulation; inflammatory bowel disease.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Antioxidants / administration & dosage
  • Antioxidants / chemistry
  • Antioxidants / therapeutic use
  • Biopolymers / chemistry
  • Colon / immunology
  • Colon / pathology
  • Dextran Sulfate
  • Disease Models, Animal*
  • Food Handling
  • Free Radical Scavengers / administration & dosage
  • Free Radical Scavengers / chemistry
  • Free Radical Scavengers / therapeutic use
  • Fruit / chemistry*
  • Gastrointestinal Agents / administration & dosage
  • Gastrointestinal Agents / chemistry
  • Gastrointestinal Agents / therapeutic use*
  • Inflammatory Bowel Diseases / diet therapy*
  • Inflammatory Bowel Diseases / immunology
  • Inflammatory Bowel Diseases / pathology
  • Intestinal Mucosa / immunology
  • Intestinal Mucosa / pathology
  • Male
  • Mice, Inbred BALB C
  • Organ Size
  • Plant Extracts / administration & dosage
  • Plant Extracts / chemistry
  • Plant Extracts / therapeutic use*
  • Prunus / chemistry*
  • Random Allocation
  • Weight Gain

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antioxidants
  • Biopolymers
  • Free Radical Scavengers
  • Gastrointestinal Agents
  • Plant Extracts
  • Dextran Sulfate