Organizing multivalency in carbohydrate recognition

Chem Soc Rev. 2016 Jun 7;45(11):3275-302. doi: 10.1039/c6cs00165c. Epub 2016 May 5.


The interactions of cell surface carbohydrates as well as of soluble glycoconjugates with their receptor proteins rule fundamental processes in cell biology. One of the supramolecular principles underlying and regulating carbohydrate recognition is multivalency. Many multivalent glycoconjugates have therefore been synthesized to study multivalency effects operative in glycobiology. This review is focused on smaller multivalent structures such as glycoclusters emphasizing carbohydrate-centered and heteromultivalent glycoconjugates. We are discussing primary, secondary and tertiary structural aspects including approaches to organize multivalency.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carbohydrate Conformation
  • Carbohydrates / chemistry*
  • Glycoconjugates / chemistry
  • Humans


  • Carbohydrates
  • Glycoconjugates