Recent advances in renal hypoxia: insights from bench experiments and computer simulations

Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F162-5. doi: 10.1152/ajprenal.00228.2016. Epub 2016 May 4.


The availability of oxygen in renal tissue is determined by the complex interactions among a host of processes, including renal blood flow, glomerular filtration, arterial-to-venous oxygen shunting, medullary architecture, Na(+) transport, and oxygen consumption. When this delicate balance is disrupted, the kidney may become susceptible to hypoxic injury. Indeed, renal hypoxia has been implicated as one of the major causes of acute kidney injury and chronic kidney diseases. This review highlights recent advances in our understanding of renal hypoxia; some of these studies were published in response to a recent Call for Papers of this journal: Renal Hypoxia.

Keywords: hypoxia; oxygen.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Acute Kidney Injury / pathology
  • Animals
  • Computer Simulation
  • Humans
  • Hypoxia / pathology*
  • Kidney Diseases / pathology*
  • Oxygen Consumption
  • Renal Insufficiency, Chronic / pathology