Cefepime-Induced Neurotoxicity Despite Dose Adjustment for Renal Disease: A Brief Report and Review of the Literature

J Pediatric Infect Dis Soc. 2017 Jun 1;6(2):199-201. doi: 10.1093/jpids/piw022.

Abstract

Cefepime is increasingly used as empiric treatment for fever in the setting of neutropenia. We present a patient with acute-on-chronic renal disease who received cefepime at the appropriate dose for his glomerular filtration rate but developed cefepime-associated encephalopathy. Here, we review neurologic toxicities of cefepime and present suggestions for work-up and management.

Keywords: cefepime; encephalopathy; leukemia; neurotoxicity; renal.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / adverse effects*
  • Cefepime
  • Cephalosporins / administration & dosage
  • Cephalosporins / adverse effects*
  • Fever of Unknown Origin / drug therapy
  • Humans
  • Male
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / complications
  • Renal Insufficiency / chemically induced*

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • Cefepime