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. 2015 Dec;3(2):10.13188/2373-1044.1000019.
doi: 10.13188/2373-1044.1000019. Epub 2015 Dec 15.

Seborrheic Dermatitis and Dandruff: A Comprehensive Review

Free PMC article

Seborrheic Dermatitis and Dandruff: A Comprehensive Review

Luis J Borda et al. J Clin Investig Dermatol. .
Free PMC article


Seborrheic Dermatitis (SD) and dandruff are of a continuous spectrum of the same disease that affects the seborrheic areas of the body. Dandruff is restricted to the scalp, and involves itchy, flaking skin without visible inflammation. SD can affect the scalp as well as other seborrheic areas, and involves itchy and flaking or scaling skin, inflammation and pruritus. Various intrinsic and environmental factors, such as sebaceous secretions, skin surface fungal colonization, individual susceptibility, and interactions between these factors, all contribute to the pathogenesis of SD and dandruff. In this review, we summarize the current knowledge on SD and dandruff, including epidemiology, burden of disease, clinical presentations and diagnosis, treatment, genetic studies in humans and animal models, and predisposing factors. Genetic and biochemical studies and investigations in animal models provide further insight on the pathophysiology and strategies for better treatment.

Keywords: Dandruff; Epidermal barrier; Malassezia; Sebaceous gland; Seborrheic dermatitis.


Figure 1
Figure 1
Predisposing factors and their interactions in the pathogenesis of seborrheic dermatitis and dandruff.

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    1. Gupta AK, Madzia SE, Batra R. Etiology and management of Seborrheic dermatitis. Dermatology. 2004;208:89–93. - PubMed
    1. Del Rosso JQ. Adult seborrheic dermatitis: a status report on practical topical management. J Clin Aesthet Dermatol. 2011;4:32–38. - PMC - PubMed
    1. Sampaio AL, Mameri AC, Vargas TJ, Ramos-e-Silva M, Nunes AP, et al. Seborrheic dermatitis. An Bras Dermatol. 2011;86:1061–1071. - PubMed
    1. Schwartz RA, Janusz CA, Janniger CK. Seborrheic dermatitis: an overview. Am Fam Physician. 2006;74:125–130. - PubMed
    1. Dessinioti C, Katsambas A. Seborrheic dermatitis: etiology, risk factors, and treatments: facts and controversies. Clin Dermatol. 2013;31:343–351. - PubMed

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