A Case of T-cell Acute Lymphoblastic Leukemia Relapsed As Myeloid Acute Leukemia

Pediatr Blood Cancer. 2016 Sep;63(9):1660-3. doi: 10.1002/pbc.26054. Epub 2016 May 3.


A 4-year-old male with the diagnosis of T-cell acute lymphoblastic leukemia (T-ALL) relapsed after 19 months with an acute myeloid leukemia (AML). Immunoglobulin and T-cell receptor gene rearrangements analyses reveal that both leukemias were rearranged with a clonal relationship between them. Comparative genomic hybridization (Array-CGH) and whole-exome sequencing analyses of both samples suggest that this leukemia may have originated from a common T/myeloid progenitor. The presence of homozygous deletion of p16/INK4A, p14/ARF, p15/INK4B, and heterozygous deletion of WT1 locus remained stable in the leukemia throughout phenotypic switch, revealing that this AML can be genetically associated to T-ALL.

Keywords: T-ALL; switch lineage; whole-exome sequencing.

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Gene Deletion
  • Gene Rearrangement, T-Lymphocyte
  • Humans
  • Leukemia, Myeloid, Acute / etiology*
  • Leukemia, Myeloid, Acute / genetics
  • Male
  • Mutation
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / complications*
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics
  • Recurrence