Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016;1438:245-54.
doi: 10.1007/978-1-4939-3661-8_14.

Murine Model for Colitis-Associated Cancer of the Colon

Affiliations
Free PMC article
Review

Murine Model for Colitis-Associated Cancer of the Colon

Ashley J Snider et al. Methods Mol Biol. .
Free PMC article

Abstract

Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), significantly increases the risk for development of colorectal cancer. Specifically, dysplasia and cancer associated with IBD (colitis-associated cancer or CAC) develop as a result of repeated cycles of injury and healing in the intestinal epithelium. Animal models are utilized to examine the mechanisms of CAC, the role of epithelial and immune cells in this process, as well as the development of novel therapeutic targets. These models typically begin with the administration of a carcinogenic compound, and inflammation is caused by repeated cycles of colitis-inducing agents. This review describes a common CAC model that utilizes the pro-carcinogenic compound azoxymethane (AOM) followed by dextran sulfate sodium (DSS) which induces the inflammatory insult.

Keywords: AOM/DSS model; Azoxymethane; Colitis-associated cancer; Dextran sulfate sodium; Inflammatory bowel disease; Murine model.

Similar articles

See all similar articles

Cited by 14 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback