Uveal Melanomas Harbor Recurrent Activating Mutations in CYSLTR2

Cancer Discov. 2016 Jun;6(6):573. doi: 10.1158/2159-8290.CD-RW2016-084. Epub 2016 May 5.

Abstract

A mutation in the CYCLTR2 G-protein-coupled receptor promotes tumorigenesis in uveal melanomas.

Publication types

  • Letter

MeSH terms

  • Cell Transformation, Neoplastic / genetics
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Melanoma / genetics*
  • Melanoma / metabolism
  • Mutation*
  • Oncogene Proteins / genetics
  • Oncogene Proteins / metabolism
  • Receptors, Leukotriene / genetics*
  • Receptors, Leukotriene / metabolism
  • Uveal Neoplasms / genetics*
  • Uveal Neoplasms / metabolism

Substances

  • Oncogene Proteins
  • Receptors, Leukotriene
  • cysteinyl leukotriene receptor 2

Supplementary concepts

  • Uveal melanoma