[Primary hyperaldosteronism due to unilateral adrenal hyperplasia with surgical resolution]

Hipertens Riesgo Vasc. 2016 Oct-Dec;33(4):155-158. doi: 10.1016/j.hipert.2016.03.002. Epub 2016 Apr 15.
[Article in Spanish]


Unilateral adrenal hyperplasia is a rare cause of primary hyperaldosteronism (around a 3%) that has surgical treatment. A case of a patient with hypertension resistant to conventional therapy in treatment with 7 drugs who presented with primary hyperaldosteronism due to unilateral adrenal hyperplasia is presented. A left adrenalectomy was performed, and the patient had a good clinical response, with no need of any drug after 2 years of surgery. Unilateral adrenal hyperplasia is a different entity and it is not an asymmetric variant of the bilateral adrenal hyperplasia. In the study of patients with primary hyperaldosteronism and imaging tests with absence of adenoma is a diagnosis that must be considered before cataloguing patients with bilateral adrenal hyperplasia and start a medical treatment, because unilateral adrenal hyperplasia would have a surgical resolution.

Keywords: Adrenal hyperplasia; Hiperaldosteronismo; Hiperplasia adrenal; Hipertensión resistente; Hyperaldosteronism; Hypertension resistant to conventional therapy.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Glands / diagnostic imaging
  • Adrenal Glands / pathology*
  • Adrenalectomy*
  • Antihypertensive Agents / therapeutic use
  • Female
  • Humans
  • Hyperaldosteronism / etiology*
  • Hyperplasia / complications
  • Hyperplasia / diagnostic imaging
  • Hyperplasia / surgery
  • Hypertension / drug therapy
  • Hypertension / surgery*
  • Magnetic Resonance Imaging
  • Middle Aged
  • Tomography, X-Ray Computed
  • Withholding Treatment


  • Antihypertensive Agents