Perioperative Rehabilitation in Operable Lung Cancer Patients (PROLUCA): A Feasibility Study

Integr Cancer Ther. 2016 Dec;15(4):455-466. doi: 10.1177/1534735416635741. Epub 2016 May 4.


Introduction Surgical resection in patients with non-small cell lung cancer (NSCLC) may be associated with significant morbidity, functional limitations, and decreased quality of life. Objectives The safety and feasibility of a preoperative and early postoperative rehabilitation program in patients operated for NSCLC was determined in a nonhospital setting, with focus on high-intensity interval exercise. Methods Forty patients with biopsy-proven NSCLC stages I to IIIa referred for surgical resection at the Department of Cardiothoracic Surgery RT, Rigshospitalet, University of Copenhagen, were randomly assigned to 1 of 4 groups (3 intervention groups and 1 control group). The preoperative intervention consisted of a home-based exercise program, while the postoperative exercise program comprised a supervised group exercise program involving resistance and high-intensity interval cardiorespiratory exercise 2 hours weekly for 12 weeks combined with individual counseling. The study endpoints were inclusion rate, adherence, and number of adverse events. Results Forty patients (of 124 screened; 32%) were included and randomized into the 4 groups. The postoperative exercise was completed by 73% of the patients randomized to this intervention. No adverse events were observed, indicating that the early postoperative exercise program is safe. The preoperative home-based exercise program was not feasible due to interfering diagnostic procedures and fast-track surgery that left only 1 to 2 weeks between diagnosis and surgery. Conclusion The early postoperative exercise program for patients with NSCLC was safe and feasible, but in a fast-track set up, a preoperative home-based exercise program was not feasible for this population.

Keywords: NSCLC; exercise; lung cancer; perioperative intervention; rehabilitation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Non-Small-Cell Lung / rehabilitation*
  • Carcinoma, Non-Small-Cell Lung / surgery*
  • Exercise / physiology
  • Exercise Therapy / methods
  • Feasibility Studies
  • Female
  • Humans
  • Lung Neoplasms / rehabilitation*
  • Lung Neoplasms / surgery*
  • Male
  • Middle Aged
  • Perioperative Period / rehabilitation*
  • Quality of Life