Intrinsic Control of Axon Regeneration

Zhigang He; Yishi Jin

doi:10.1016/j.neuron.2016.04.022

Intrinsic Control of Axon Regeneration

Neuron. 2016 May 4;90(3):437-51. doi: 10.1016/j.neuron.2016.04.022.

Authors

Zhigang He¹, Yishi Jin²

Affiliations

¹ F.M. Kirby Neurobiology Center, Boston Children's Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. Electronic address: zhigang.he@childrens.harvard.edu.
² Section of Neurobiology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: yijin@ucsd.edu.

PMID: 27151637
DOI: 10.1016/j.neuron.2016.04.022

Abstract

A determinant of axon regeneration is the intrinsic growth ability of injured neurons, which dictates a battery of injury responses in axons and cell bodies. While some of these regulatory mechanisms are evolutionarily conserved, others are unique to the mammalian central nervous system (CNS) where spontaneous regeneration usually does not occur. Here we examine our current understanding of these mechanisms at cellular and molecular terms and discuss their potential implications for promoting axon regeneration and functional recovery after nerve injury.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Axons / physiology*
Central Nervous System / physiology*
Humans
Models, Theoretical
Nerve Regeneration / physiology*
Neurons / physiology*
Recovery of Function / physiology*

Abstract

Publication types

MeSH terms

Grants and funding