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Review
. 2015 Aug;5(Suppl 1):S11-4.
doi: 10.1038/ijosup.2015.4. Epub 2015 Aug 4.

Promoting Brown and Beige Adipocyte Biogenesis Through the PRDM16 Pathway

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Free PMC article
Review

Promoting Brown and Beige Adipocyte Biogenesis Through the PRDM16 Pathway

S Kajimura. Int J Obes Suppl. .
Free PMC article

Abstract

Obesity develops from a chronic energy imbalance in which energy intake exceeds energy expenditure. As brown adipose tissue (BAT) dissipates energy and produces heat, increasing energy expenditure via BAT thermogenesis may constitute a novel therapeutic intervention for the treatment of obesity and obesity-related diseases. Studies over the past few years have identified key regulatory molecules of brown and beige adipocyte biogenesis, including a dominant transcriptional co-regulator PRDM16 (PR domain containing 16) and its co-factors, which allows for engineering functional BAT by genetic approaches. A next step toward the goal of promoting BAT thermogenesis by pharmacological approaches necessitates a better understanding of the enzymatic components and signaling pathways for brown and beige adipocyte development. This review covers recent advances regarding this topic, with a special emphasis on the PRDM16 transcriptional pathway.

Figures

Figure 1
Figure 1
(a) Function of the PRDM16 transcriptional complex in brown adipocyte differentiation. (b) Molecular mechanisms of TZD-induced beige adipocyte differentiation by PRDM16.

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