Survival outcomes after endoscopic resection for sinonasal squamous cell carcinoma arising on inverted papilloma

Head Neck. 2016 Nov;38(11):1604-1614. doi: 10.1002/hed.24481. Epub 2016 May 6.


Background: Sinonasal inverted papillomas (IPs) can be associated synchronously or metachronously to invasive squamous cell carcinoma (SCC) in 5% to 10% of cases. The purposes of the present study were to analyze the outcomes of patients with sinonasal SCC arising from inverted papilloma (IP-SCC) treated through an endoscopic approach and review the pertinent literature.

Methods: The medical records of all patients treated for IP-SCC between 1997 and 2014 at 2 referral centers following a uniform policy were retrospectively analyzed.

Results: Thirty-four patients fulfilled the inclusion criteria. The 5-year overall survival (OS), disease-specific survival (DFS), and recurrence-free survival (RFS) rates were 66.8 ± 0.99%, 71.2 ± 0.96%, and 73.1 ± 0.82%, respectively. Multivariate analysis revealed that the advanced pT classification (pT3 or greater), the high-grade of tumoral differentiation, the cranioendoscopic approach, and the recurrence of disease impacted negatively on survival rates.

Conclusion: The endoscopic approach provides encouraging oncologic outcomes for sinonasal IP-SCC, comparable to those observed with traditional external approaches while minimizing morbidity for patients. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1708-1716, 2016.

Keywords: endoscopic endonasal approach; inverted papilloma; paranasal sinuses; radiotherapy; sinonasal cancer; skull base; squamous cell carcinoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Squamous Cell / mortality*
  • Carcinoma, Squamous Cell / pathology
  • Carcinoma, Squamous Cell / surgery
  • Endoscopy
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Grading
  • Neoplasms, Second Primary / mortality*
  • Neoplasms, Second Primary / surgery
  • Papilloma, Inverted*
  • Paranasal Sinus Neoplasms / mortality*
  • Paranasal Sinus Neoplasms / pathology
  • Paranasal Sinus Neoplasms / surgery
  • Proportional Hazards Models
  • Retrospective Studies
  • Survival Analysis
  • Survival Rate