Emerging Trends in Nonsurgical Female Genital Rejuvenation

Dermatol Surg. 2016 Sep;42(9):1019-29. doi: 10.1097/DSS.0000000000000697.


Background: Aging, childbearing, and hormonal changes can lead to vulvovaginal laxity and mucosal atrophy that negatively affect a woman's quality of life. As more minimally and noninvasive options for genital rejuvenation become available in the outpatient setting, it becomes increasingly important for the dermatologic surgeon to be familiar with these popular procedures.

Objective: To familiarize dermatologists with the nonsurgical options available for female genital rejuvenation, patient motivations for pursuing these procedures, relevant anatomy, and potential adverse events.

Materials and methods: A MEDLINE search was performed on nonsurgical female genital rejuvenation from 1989 to 2015, and results are summarized.

Results: Reports of nonsurgical female genital rejuvenation procedures using fractional carbon dioxide lasers, nonablative lasers, monopolar radiofrequency devices, hyaluronic acid fillers, and fat transfer are concisely summarized for the practicing dermatologist.

Conclusion: Review of the literature revealed expanding options for nonsurgical female genital rejuvenation.

MeSH terms

  • Adipose Tissue / transplantation
  • Administration, Topical
  • Dermal Fillers / therapeutic use*
  • Estrogens / administration & dosage
  • Female
  • Humans
  • Laser Therapy
  • Platelet-Rich Plasma
  • Radiofrequency Therapy*
  • Rejuvenation*
  • Skin Cream
  • Vagina / anatomy & histology
  • Vagina / drug effects
  • Vagina / physiology*
  • Vagina / radiation effects
  • Vulva / anatomy & histology
  • Vulva / drug effects
  • Vulva / physiology*
  • Vulva / radiation effects


  • Dermal Fillers
  • Estrogens