Thoughts on Obesity and Brain Glucose

Michael T Heneka; Pierluigi Nicotera

doi:10.1016/j.cell.2016.04.057

Thoughts on Obesity and Brain Glucose

Cell. 2016 May 5;165(4):773-5. doi: 10.1016/j.cell.2016.04.057.

Authors

Michael T Heneka¹, Pierluigi Nicotera²

Affiliations

¹ DZNE, The German Center for Neurodegenerative Diseases and University of Bonn, Ludwig Erhard Alle, 2, 53175 Bonn, Germany.
² DZNE, The German Center for Neurodegenerative Diseases and University of Bonn, Ludwig Erhard Alle, 2, 53175 Bonn, Germany. Electronic address: pierluigi.nicotera@dzne.de.

PMID: 27153489
DOI: 10.1016/j.cell.2016.04.057

Abstract

Homeostatic control of brain metabolism is essential for neuronal activity. Jais et al., (2016) report that reduced brain glucose uptake elicited by a high-fat diet self-corrects by the recruitment of peripheral, VEGF-producing macrophages to the blood-brain barrier. Their findings further suggest that restoring brain glucose availability might help protect from cognitive impairment in Alzheimer's disease.

Publication types

Comment

MeSH terms

Alzheimer Disease / metabolism
Brain / metabolism*
Diet, High-Fat
Glucose / metabolism*
Humans
Obesity / metabolism

Substances

Glucose