Neuro-Immune Interactions at Barrier Surfaces

Cell. 2016 May 5;165(4):801-11. doi: 10.1016/j.cell.2016.04.041.


Multidirectional interactions between the nervous and immune systems have been documented in homeostasis and pathologies ranging from multiple sclerosis to autism, and from leukemia to acute and chronic inflammation. Recent studies have addressed this crosstalk using cell-specific targeting, novel sequencing, imaging, and analytical tools, shedding light on unappreciated mechanisms of neuro-immune regulation. This Review focuses on neuro-immune interactions at barrier surfaces-mostly the gut, but also including the skin and the airways, areas densely populated by neurons and immune cells that constantly sense and adapt to tissue-specific environmental challenges.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Hematopoiesis
  • Humans
  • Immune System / metabolism*
  • Intestinal Mucosa / immunology
  • Intestinal Mucosa / innervation
  • Intestines / immunology
  • Intestines / innervation
  • Lymphoid Tissue / immunology
  • Lymphoid Tissue / physiology
  • Mucous Membrane / immunology*
  • Mucous Membrane / innervation*
  • Nervous System / anatomy & histology*
  • Nervous System / metabolism
  • Neurons / cytology