FRODOCK 2.0: fast protein-protein docking server

Bioinformatics. 2016 Aug 1;32(15):2386-8. doi: 10.1093/bioinformatics/btw141. Epub 2016 Mar 12.


The prediction of protein-protein complexes from the structures of unbound components is a challenging and powerful strategy to decipher the mechanism of many essential biological processes. We present a user-friendly protein-protein docking server based on an improved version of FRODOCK that includes a complementary knowledge-based potential. The web interface provides a very effective tool to explore and select protein-protein models and interactively screen them against experimental distance constraints. The competitive success rates and efficiency achieved allow the retrieval of reliable potential protein-protein binding conformations that can be further refined with more computationally demanding strategies.

Availability and implementation: The server is free and open to all users with no login requirement at


Supplementary information: Supplementary data are available at Bioinformatics online.

MeSH terms

  • Computers*
  • Protein Conformation*
  • Proteins
  • Software


  • Proteins