Reaction Decoder Tool (RDT): extracting features from chemical reactions

Bioinformatics. 2016 Jul 1;32(13):2065-6. doi: 10.1093/bioinformatics/btw096. Epub 2016 Feb 22.

Abstract

Extracting chemical features like Atom-Atom Mapping (AAM), Bond Changes (BCs) and Reaction Centres from biochemical reactions helps us understand the chemical composition of enzymatic reactions. Reaction Decoder is a robust command line tool, which performs this task with high accuracy. It supports standard chemical input/output exchange formats i.e. RXN/SMILES, computes AAM, highlights BCs and creates images of the mapped reaction. This aids in the analysis of metabolic pathways and the ability to perform comparative studies of chemical reactions based on these features.

Availability and implementation: This software is implemented in Java, supported on Windows, Linux and Mac OSX, and freely available at https://github.com/asad/ReactionDecoder

Contact: : asad@ebi.ac.uk or s9asad@gmail.com.

MeSH terms

  • Biochemistry / methods*
  • Computational Biology / methods*
  • Data Mining
  • Databases, Chemical
  • Metabolic Networks and Pathways*
  • Software*