High-performance web services for querying gene and variant annotation

Genome Biol. 2016 May 6;17(1):91. doi: 10.1186/s13059-016-0953-9.


Efficient tools for data management and integration are essential for many aspects of high-throughput biology. In particular, annotations of genes and human genetic variants are commonly used but highly fragmented across many resources. Here, we describe MyGene.info and MyVariant.info, high-performance web services for querying gene and variant annotation information. These web services are currently accessed more than three million times permonth. They also demonstrate a generalizable cloud-based model for organizing and querying biological annotation information. MyGene.info and MyVariant.info are provided as high-performance web services, accessible at http://mygene.info and http://myvariant.info . Both are offered free of charge to the research community.

Keywords: API; Annotation; Cloud; Database; Gene; Repository; Variant.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Database Management Systems
  • Databases, Genetic
  • Genetic Variation*
  • Humans
  • Internet
  • Molecular Sequence Annotation*
  • Sequence Analysis, DNA*
  • Software*
  • User-Computer Interface