Contact phase of blood coagulation in cardiogenic pulmonary oedema (CPO) and adult respiratory distress syndrome (ARDS)

Intensive Care Med. 1989;15(2):99-104. doi: 10.1007/BF00295985.


In order to assess the role of the kallikreinkinin (k-k) system in the pathogenesis of pulmonary oedema, we studied the contact phase factors of blood coagulation, as well as the haemodynamics and blood gas changes in 34 patients with pulmonary oedema, 23 of them with Adult Respiratory Distress Syndrome (ARDS) and 11 with cardiogenic pulmonary oedema (CPO). We have verified significant differences in the haemodynamic pattern and blood gases between the two groups of patients, which corroborate the previously established differences between both types of pulmonary oedema. Our results reveal k-k system activation in ARDS patients, with a significant fall in factor XII (p less than 0.05), prekallikrein (p less than 0.01), alpha-2-macroglobulin (p less than 0.01) and high molecular - weight kininogens (p less than 0.005), with a rise in C1-esterase inhibitor (p less than 0.001) in comparison with patients with CPO. All of the CPO patients had normal prekallikrein levels, whereas 15 out 23 ARDS cases (65%) had decreased prekallikrein values. Our results suggest that the k-k system activation could play a role in the pathogenesis of ARDS. Estimation of prekallikrein levels may be helpful in the differential diagnosis of ARDS.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Blood Coagulation*
  • Blood Gas Analysis
  • Diagnosis, Differential
  • Female
  • Hemodynamics
  • Humans
  • Male
  • Middle Aged
  • Prekallikrein / blood
  • Pulmonary Edema / blood*
  • Pulmonary Edema / diagnosis
  • Pulmonary Edema / enzymology
  • Respiratory Distress Syndrome / blood*
  • Respiratory Distress Syndrome / diagnosis
  • Respiratory Distress Syndrome / enzymology


  • Prekallikrein