Toxicokinetics of ochratoxin A in several species and its plasma-binding properties

J Appl Toxicol. 1989 Apr;9(2):91-6. doi: 10.1002/jat.2550090204.


The toxicokinetic profile of ochratoxin A was studied after the oral or intravenous administration of 50 ng/g b.w. to fish, quail, mouse, rat and monkey. The elimination half-life varied from 0.68 h after oral administration to fish, up to 840 h after intravenous administration to monkey. The distribution volume ranged from 57 ml/kg in fish to 1500 ml/kg in quail. The plasma clearance was most rapid in quail and fish, 72 and 58 ml/kg.h, respectively, while it was only 0.17 ml/kg.h in monkey. The bioavailability was as low as 1.6% in fish but as high as 97% in mouse. The binding abilities of ochratoxin A to plasma proteins were also studied. From these data we calculated the free fraction of toxin in plasma, which we found to be less than 0.2% in all species investigated (including man) except fish. A similar but smaller investigation on the toxicokinetics and binding properties of ochratoxin B was also performed. Ochratoxin B was more readily eliminated and had a lower affinity for plasma proteins, which partly may explain its lower toxicity.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Biological Availability
  • Blood Proteins / metabolism
  • Carps
  • Coturnix
  • Humans
  • Injections, Intravenous
  • Kidney / metabolism
  • Macaca mulatta
  • Male
  • Mice
  • Ochratoxins / pharmacokinetics
  • Ochratoxins / toxicity*
  • Protein Binding
  • Rats
  • Rats, Inbred Strains
  • Species Specificity


  • Blood Proteins
  • Ochratoxins
  • ochratoxin A