[Meta-analysis of the side-effect profiles of modern radiation therapies for patients with prostate cancer]

Orv Hetil. 2016 May 15;157(20):776-88. doi: 10.1556/650.2016.30422.
[Article in Hu]


Introduction: One of the most relevant focus of recent developments in radiotherapy technology was the adequate irradiation of prostate cancer.

Aim: The aim of this study was to analyse the safety of normo- and hypofractionated and high dose intensity-modulated radiotherapy.

Method: Toxicities were identified through literature review and evidence was synthetized with meta-analytical methods.

Results: The use of high dose intensity-modulated radiotherapy resulted in no difference in severe genitourinary (acute p = 0.9; late p = 0.95) and moderate or severe gastrointestinal (acute: N/A; late: p = 0.08) toxicities compared to 3D conformal radiation therapy. The risk ratio of moderate acute (RR = 1.39, 95% CI: 1.09-1.78; p = 0.008) and late genitourinary toxicities (RR = 1.48, 95% CI: 1.26-1.75; p<0,00001) was higher. There was no difference in hypo- and normofractionated intensity-modulated radiotherapy regarding severe genitourinary (acute: N/A; late: p = 0.73) and moderate or severe gastrointestinal (acute: p = 0.73; late: p = 0.55) toxicities, the risk of late moderate genitourinary toxicities was higher when using hypofractionation scheme (RR = 1.39, 95% CI: 1.00-1.94; p = 0.05).

Conclusions: The use of normo- and hypofractionated and high dose intensity-modulated radiotherapy proved to be safe. However the higher risk of moderate genitourinary adverse events require an extensive clinical risk estimation.

Keywords: dose hypofractionation; hipofrakcionálás; meta-analysis; metaanalízis; prostatic neoplasm; prosztatarák; radiotherapy; sugárterápia.

Publication types

  • Meta-Analysis

MeSH terms

  • Aged
  • Aged, 80 and over
  • Dose Fractionation, Radiation
  • Gastrointestinal Tract / radiation effects*
  • Humans
  • Male
  • Prostatic Neoplasms / radiotherapy*
  • Radiation Injuries / etiology*
  • Radiotherapy Dosage
  • Radiotherapy, Conformal / adverse effects*
  • Radiotherapy, Intensity-Modulated / adverse effects
  • Urogenital System / radiation effects*