Acute Foramen Magnum Syndrome Following Single Diagnostic Lumbar Puncture: Consequence of a Small Posterior Fossa?

Abstract

Background: Type I Chiari malformation (CMI) is a rare complication of lumbar cerebrospinal fluid (CSF) drainage that is usually reported after lumbar drain or lumboperitoneal shunt placement. It usually remains asymptomatic; however, even if it becomes symptomatic, symptoms are usually mild. There are only a few reports of acute foramen magnum syndrome following continuous lumbar CSF drainage, and acute foramen magnum syndrome after a single diagnostic lumbar puncture (LP) has not been previously reported. We encountered this catastrophic complication in one of our patient.

Case description: A 30-year-old woman with a large supratentorial meningioma and associated asymptomatic CMI presented with holocranial headache. She underwent successful and uneventful excision of the tumor. However, she developed quadriplegia and respiratory arrest 48 hours following a diagnostic LP performed on postoperative day 9. She underwent urgent posterior fossa decompression after magnetic resonance imaging showed increased tonsillar impaction and swelling along with cervicomedullary compression. Postoperatively, she steadily improved and regained normal power after 3 months. Retrospective quantitative analysis of magnetic resonance imaging (MRI) revealed a small posterior fossa.

Conclusions: The association of intracranial tumors and lumbar CSF drainage with CMI is uncommon. The documentation of a small posterior fossa signifies the importance of both developmental (small posterior fossa) and acquired (intracranial tumor/lumbar CSF drainage) factors in pathogenesis of CMI. Although the extreme rarity of acute deterioration following a single LP does not warrant LP to be contraindicated in such patients, documentation of resolution of CMI with postoperative MRI before performing lumbar CSF drainage (whether therapeutic or diagnostic), might be helpful in avoiding this rare complication.

Keywords: Diagnostic lumbar puncture; Posterior cranial fossa volume; Supratentorial tumor; Type I Chiari malformation.