Long Non-coding RNAs in the Cytoplasm

Genomics Proteomics Bioinformatics. 2016 Apr;14(2):73-80. doi: 10.1016/j.gpb.2016.03.005. Epub 2016 May 6.


An enormous amount of long non-coding RNAs (lncRNAs) transcribed from eukaryotic genome are important regulators in different aspects of cellular events. Cytoplasm is the residence and the site of action for many lncRNAs. The cytoplasmic lncRNAs play indispensable roles with multiple molecular mechanisms in animal and human cells. In this review, we mainly talk about functions and the underlying mechanisms of lncRNAs in the cytoplasm. We highlight relatively well-studied examples of cytoplasmic lncRNAs for their roles in modulating mRNA stability, regulating mRNA translation, serving as competing endogenous RNAs, functioning as precursors of microRNAs, and mediating protein modifications. We also elaborate the perspectives of cytoplasmic lncRNA studies.

Keywords: MicroRNA; ceRNA; lncRNA; mRNA stability; mRNA translation.

Publication types

  • Review

MeSH terms

  • Animals
  • Cytoplasm / metabolism*
  • Humans
  • MicroRNAs / genetics
  • MicroRNAs / metabolism
  • Phosphorylation
  • Protein Biosynthesis / genetics
  • RNA Precursors / metabolism
  • RNA Stability
  • RNA, Long Noncoding / genetics
  • RNA, Long Noncoding / metabolism*
  • Ubiquitination


  • MicroRNAs
  • RNA Precursors
  • RNA, Long Noncoding