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Ionone Derivatives From the Mycelium of Phellinus Linteus and the Inhibitory Effect on Activated Rat Hepatic Stellate Cells

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Ionone Derivatives From the Mycelium of Phellinus Linteus and the Inhibitory Effect on Activated Rat Hepatic Stellate Cells

Shiow-Chyn Huang et al. Int J Mol Sci.

Abstract

Three new γ-ionylideneacetic acid derivatives, phellinulins A-C (1-3), were characterized from the mycelium extract of Phellinus linteus. The chemical structures were established based on the spectroscopic analysis. In addition, phellinulin A (1) was subjected to the examination of effects on activated rat hepatic stellate cells and exhibited significant inhibition of hepatic fibrosis.

Keywords: Phellinus linteus; fungus; hepatic fibrosis; ionone; phellinulin.

Figures

Figure 1
Figure 1
Chemical structures of phellinulins A–C (13).
Figure 2
Figure 2
Significant HMBC (→) and NOESY (↔) correlations of compound 1.
Figure 3
Figure 3
Western blot analysis of PLE and phellinulin A (1).

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