Anti-diabetic effect of citrus pectin in diabetic rats and potential mechanism via PI3K/Akt signaling pathway

Int J Biol Macromol. 2016 Aug:89:484-8. doi: 10.1016/j.ijbiomac.2016.05.015. Epub 2016 May 6.


This study was performed to investigate the anti-diabetic effect of citrus pectin in type 2 diabetic rats and its potential mechanism of action. The results showed that fasting blood glucose levels were significantly decreased after 4 weeks of citrus pectin administration. Citrus pectin improved glucose tolerance, hepatic glycogen content and blood lipid levels (TG, TC, LDL-c and HDL-c) in diabetic rats. Citrus pectin also significantly reduced insulin resistance, which played an important role in the resulting anti-diabetic effect. Moreover, after the pectin treatment, phosphorylated Akt expression was upregulated and GSK3β expression was downregulated, indicating that the potential anti-diabetic mechanism of citrus pectin might occur through regulation of the PI3K/Akt signaling pathway. Together, these results suggested that citrus pectin could ameliorate type 2 diabetes and potentially be used as an adjuvant treatment.

Keywords: Citrus pectin; Insulin signaling pathway; Type 2 diabetes.

MeSH terms

  • Animals
  • Blood Glucose / drug effects
  • Diabetes Mellitus, Experimental / blood
  • Diabetes Mellitus, Experimental / drug therapy*
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Gene Expression / drug effects
  • Glycogen Synthase Kinase 3 beta / blood*
  • Humans
  • Oncogene Protein v-akt / blood*
  • Pectins / administration & dosage*
  • Phosphatidylinositol 3-Kinases / blood
  • Rats
  • Signal Transduction / drug effects


  • Blood Glucose
  • citrus pectin
  • Pectins
  • Phosphatidylinositol 3-Kinases
  • Glycogen Synthase Kinase 3 beta
  • Gsk3b protein, rat
  • Oncogene Protein v-akt