Cannabis for Refractory Psoriasis-High Hopes for a Novel Treatment and a Literature Review

Curr Clin Pharmacol. 2016;11(2):146-7. doi: 10.2174/1574884711666160511150126.


Psoriasis is a common skin disorder characterized by hyper proliferation of keratinocytes. Although the exact pathophysiology of psoriasis is not entirely understood, immune system and its interaction with nervous system have been postulated and investigated as the underlying mechanism. The interaction between these two systems through cholinergic anti-inflammatory pathway and also endocannabinoid system, may suggest cannabinoids as potential addition to antipsoriatic armamentarium.

Publication types

  • Review

MeSH terms

  • Cannabinoids / administration & dosage*
  • Cannabinoids / pharmacology
  • Cell Proliferation
  • Dermatologic Agents / administration & dosage
  • Dermatologic Agents / pharmacology
  • Endocannabinoids / metabolism*
  • Humans
  • Keratinocytes / metabolism
  • Psoriasis / drug therapy*
  • Psoriasis / immunology
  • Psoriasis / pathology


  • Cannabinoids
  • Dermatologic Agents
  • Endocannabinoids