A Wounded Nucleus Needs ESCRT Service

Rosemarie Ungricht; Ulrike Kutay

doi:10.1016/j.devcel.2016.04.012

A Wounded Nucleus Needs ESCRT Service

Dev Cell. 2016 May 9;37(3):202-4. doi: 10.1016/j.devcel.2016.04.012.

Authors

Rosemarie Ungricht¹, Ulrike Kutay²

Affiliations

¹ Institute of Biochemistry, ETH Zurich, 8093 Zurich, Switzerland.
² Institute of Biochemistry, ETH Zurich, 8093 Zurich, Switzerland. Electronic address: ulrike.kutay@bc.biol.ethz.ch.

PMID: 27165549
DOI: 10.1016/j.devcel.2016.04.012

Abstract

Two recent publications in Science report on frequent rupturing events of the nuclear envelope induced by migration of cells through narrow openings. Nuclear envelope "wounds" are repaired by the ESCRT-III machinery to limit DNA damage, nuclear fragmentation, and cell death.

MeSH terms

Animals
Cell Nucleus / metabolism*
Endosomal Sorting Complexes Required for Transport / metabolism*
Humans
Models, Biological
Nuclear Envelope / metabolism

Substances

Endosomal Sorting Complexes Required for Transport