Head of the Class: OLIG2 and Glioblastoma Phenotype

Cancer Cell. 2016 May 9;29(5):613-615. doi: 10.1016/j.ccell.2016.04.007.


Genomic mapping has driven the classification of glioblastoma into distinct molecular subclasses, but mechanisms that regulate tumor subclass phenotypes are only now emerging. In this issue of Cancer Cell, Lu et al. describe a phenotypic switch from PDGFRA-enriched "proneural" to EGFR-enriched "classical" features in glioblastoma upon ablation of Olig2.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Brain Neoplasms / genetics*
  • Glioblastoma / genetics*
  • Humans
  • Phenotype
  • Transcription Factors / genetics


  • Transcription Factors