Galectin-3 in Renal Pathology: More Than Just an Innocent Bystander

Am J Nephrol. 2016;43(5):305-17. doi: 10.1159/000446376. Epub 2016 May 12.

Abstract

Background: Galectin-3 is a member of a closely related lectin family, which is detected in several vertebrate epithelial and myeloid cell types. This beta-galactoside-binding soluble protein plays an important role in multiple biological processes. Depending on its location, type of injury or site of damage, the effects by galectin-3 can be various and sometimes contrasting.

Summary: In this review, we discuss the general characteristics and functions of galectin-3. More specifically, we focus on the role of galectin-3 in the onset and development of diabetic and non-diabetic nephropathies. Finally, the therapeutic potential of anti-galectin-3 inhibitors is discussed.

Key messages: Due to its multifunctional character, galectin-3 plays a pivotal role in interstitial fibrosis and progression of chronic kidney disease. Inhibition of galectin-3 may be a promising therapeutic strategy to prevent end-stage renal disease.

Publication types

  • Review

MeSH terms

  • Animals
  • Galectin 3 / antagonists & inhibitors
  • Galectin 3 / metabolism*
  • Humans
  • Kidney Diseases / drug therapy
  • Kidney Diseases / etiology*
  • Kidney Diseases / metabolism

Substances

  • Galectin 3