17-Hydroxyprogesterone responses to human chorionic gonadotropin are not associated with serum anti-Mullerian hormone levels among adolescent girls with polycystic ovary syndrome

J Pediatr Endocrinol Metab. 2016 Jul 1;29(7):835-40. doi: 10.1515/jpem-2015-0461.


Background: In adult women with polycystic ovary syndrome (PCOS) 17-OHP responses to human chorionic gonadotropin (hCG) stimulation are highly variable and inversely correlated with serum anti-Mullerian hormone (AMH) levels. The objective of this study was to determine whether adolescents with PCOS exhibit similar variable 17-OHP responsiveness to hCG and whether these responses are correlated to AMH levels.

Methods: In a prospective study, adolescent PCOS (n=14) and normal controls (n=10) received 25 μg of hCG, intravenously. Blood samples were obtained before and 24 h afterwards for measurement of 17-OHP and basal AMH.

Results: Variable 17-OHP responses to hCG were observed among PCOS girls similar to that observed in adults. There was no correlation between AMH and 17-OHP responses to hCG.

Conclusions: Among adult and adolescent individuals with PCOS variable 17-OHP production appears to be characteristic of the disorder. In adolescent PCOS, 17-OHP responsiveness to hCG is not correlated to AMH.

Publication types

  • Controlled Clinical Trial
  • Multicenter Study

MeSH terms

  • 17-alpha-Hydroxyprogesterone / blood*
  • Adolescent
  • Androstenedione / blood
  • Anti-Mullerian Hormone / blood*
  • California
  • Child
  • Chorionic Gonadotropin / administration & dosage
  • Chorionic Gonadotropin / genetics
  • Chorionic Gonadotropin / therapeutic use*
  • Dehydroepiandrosterone / blood
  • Female
  • Fertility Agents, Female / administration & dosage
  • Fertility Agents, Female / therapeutic use*
  • Humans
  • Injections, Intravenous
  • Polycystic Ovary Syndrome / blood
  • Polycystic Ovary Syndrome / drug therapy*
  • Recombinant Proteins / therapeutic use
  • Reproducibility of Results
  • Testosterone / blood
  • Virginia


  • Chorionic Gonadotropin
  • Fertility Agents, Female
  • Recombinant Proteins
  • Testosterone
  • Androstenedione
  • Dehydroepiandrosterone
  • 17-alpha-Hydroxyprogesterone
  • Anti-Mullerian Hormone