PepPSy: a web server to prioritize gene products in experimental and biocuration workflows

Database (Oxford). 2016 May 12;2016:baw070. doi: 10.1093/database/baw070. Print 2016.

Abstract

Among the 20 000 human gene products predicted from genome annotation, about 3000 still lack validation at protein level. We developed PepPSy, a user-friendly gene expression-based prioritization system, to help investigators to determine in which human tissues they should look for an unseen protein. PepPSy can also be used by biocurators to revisit the annotation of specific categories of proteins based on the 'omics' data housed by the system. In this study, it was used to prioritize 21 dubious protein-coding genes among the 616 annotated in neXtProt for reannotation. PepPSy is freely available at http://peppsy.genouest.orgDatabase URL: http://peppsy.genouest.org.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computational Biology
  • Database Management Systems
  • Databases, Genetic*
  • Humans
  • Internet*
  • Molecular Sequence Annotation
  • Proteins / genetics*
  • User-Computer Interface*
  • Workflow

Substances

  • Proteins