What's LPS Got to Do with It? A Role for Gut LPS Variants in Driving Autoimmune and Allergic Disease

Cell Host Microbe. 2016 May 11;19(5):572-4. doi: 10.1016/j.chom.2016.04.025.


The bacterial communities that live in and on our bodies have a profound influence on our health. In a new paper in Cell, Vatanen et al. (2016) report that the composition of the early-life gut microbiome, particularly those species producing lipopolysaccharide, influences the onset of autoimmune and allergic disease.

MeSH terms

  • Autoimmune Diseases / immunology*
  • Bacteria / genetics
  • Bacteria / metabolism
  • Endotoxins / immunology
  • Gastrointestinal Microbiome / immunology*
  • Gastrointestinal Tract / immunology*
  • Gastrointestinal Tract / microbiology*
  • Humans
  • Hypersensitivity / immunology*
  • Immunity, Innate
  • Lipopolysaccharides / immunology*


  • Endotoxins
  • Lipopolysaccharides
  • endotoxin, Escherichia coli