Effectiveness and Safety of Large Gel Particle Hyaluronic Acid With Lidocaine for Correction of Midface Volume Deficit or Contour Deficiency

Dermatol Surg. 2016 Jun;42(6):699-709. doi: 10.1097/DSS.0000000000000771.

Abstract

Background: Aging effects, such as facial flatness, increased tissue laxity, and soft tissue descent and deflation, contribute to midface deficiency.

Objective: To evaluate whether large gel particle hyaluronic acid with lidocaine (LGP-HAL) is more effective in the treatment of midface deficiencies than no treatment.

Materials and methods: Subjects with mild to substantial loss of midface fullness were randomized 3:1 to LGP-HAL (Restylane Lyft; Galderma Laboratories, L.P., Fort Worth, TX) or no treatment. Treatment success was defined as at least 1-grade improvement in Medicis Midface Volume Scale (MMVS) on each side of the face at 8 weeks as assessed by a blinded evaluator. Secondary efficacy end points included MMVS score, global aesthetic improvement, and subject satisfaction.

Results: Significantly greater percent of subjects achieved treatment success in the LGP-HAL group compared to no treatment at all time points through Month 12 (p < .001). One year after initial treatment, 85% of subjects still had a global aesthetic improvement assessed by the treating investigator. Subject satisfaction demonstrated that LGP-HAL improved the aesthetic appearance of the midface. Most reported adverse events (80%) were mild in severity.

Conclusion: The LGP-HAL treatment is well tolerated and provides significant improvement up to 12 months for the correction of midface deficiencies.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Anesthetics, Local / administration & dosage*
  • Anesthetics, Local / adverse effects
  • Cosmetic Techniques* / adverse effects
  • Esthetics
  • Face*
  • Female
  • Gels
  • Humans
  • Hyaluronic Acid / administration & dosage*
  • Hyaluronic Acid / adverse effects
  • Lidocaine / administration & dosage*
  • Lidocaine / adverse effects
  • Male
  • Middle Aged
  • Patient Safety
  • Patient Satisfaction
  • Single-Blind Method
  • Skin Aging*
  • Surveys and Questionnaires
  • Treatment Outcome
  • United States
  • Viscosupplements / administration & dosage*
  • Viscosupplements / adverse effects

Substances

  • Anesthetics, Local
  • Gels
  • Viscosupplements
  • Hyaluronic Acid
  • Lidocaine