Vitamin D deficiency and lower respiratory tract infections in children: a systematic review and meta-analysis of observational studies

Trop Doct. 2017 Jan;47(1):77-84. doi: 10.1177/0049475516644141. Epub 2016 May 13.

Abstract

Studies related to vitamin D deficiency and lower respiratory tract infections (LRTI) in children have inconsistent findings. The objective of this systematic review was to assess the prevalence of vitamin D deficiency in children with LRTI, and to evaluate the correlation between vitamin D levels and the incidence and severity of LRTI. A total of 12 studies enrolling 2279 participants were included in our analysis. Children with LRTI were found to have significantly lower mean vitamin D levels as compared to controls There was likewise a correlation between vitamin D levels and incidence and severity of LRTI. Large randomised controlled trials are needed to evaluate effect of vitamin D supplementation for LRTI.

Keywords: Vitamin D; case-control study; cohort; lower respiratory tract infection (LRTI).

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Child
  • Dietary Supplements
  • Humans
  • Prevalence
  • Respiratory Tract Infections / epidemiology
  • Respiratory Tract Infections / etiology*
  • Vitamin D / therapeutic use
  • Vitamin D Deficiency / complications*
  • Vitamin D Deficiency / drug therapy
  • Vitamins / therapeutic use

Substances

  • Vitamins
  • Vitamin D