New insights into basophil heterogeneity

Semin Immunopathol. 2016 Sep;38(5):549-61. doi: 10.1007/s00281-016-0567-z. Epub 2016 May 13.

Abstract

Basophils have become increasingly recognized as important innate immune cells that mediate antihelminth immunity and barrier inflammation. Recent discoveries have uncovered previously unrecognized heterogeneity in basophil populations. However, how diversity in basophil regulation and function impacts human disease remains poorly defined. The goal of the present review is to highlight how new insights into basophil heterogeneity can help us to better understand disease pathogenesis and inform the development of new therapeutics.

Publication types

  • Review

MeSH terms

  • Animals
  • Basophils / cytology*
  • Basophils / physiology*
  • Bone Marrow Cells / cytology
  • Bone Marrow Cells / metabolism
  • Cell Communication / genetics
  • Cell Communication / immunology
  • Cell Differentiation
  • Cytokines / metabolism
  • Disease Susceptibility
  • Extracellular Space / metabolism
  • Hematopoiesis
  • Hematopoietic Stem Cells / cytology
  • Hematopoietic Stem Cells / metabolism
  • Humans
  • Immunoglobulin E / immunology
  • Immunoglobulin E / metabolism
  • Interleukin-3 / metabolism
  • Intracellular Space / metabolism
  • Signal Transduction

Substances

  • Cytokines
  • Interleukin-3
  • Immunoglobulin E
  • thymic stromal lymphopoietin