Cutaneous manifestations of lung cancer

Semin Oncol. 2016 Jun;43(3):366-9. doi: 10.1053/j.seminoncol.2016.02.025. Epub 2016 Feb 23.


Skin findings can serve as a clue to internal disease. In this article, cutaneous manifestations of underlying lung malignancy are reviewed. Paraneoplastic dermatoses are rare, but when recognized early, can lead to early diagnosis of an underlying neoplasm. Malignancy-associated dermatoses comprise a broad group of hyperproliferative and inflammatory disorders, disorders caused by tumor production of hormonal or metabolic factors, autoimmune connective tissue diseases, among others. In this review, paraneoplastic syndromes associated with lung malignancy are discussed, including ectopic ACTH syndrome, bronchial carcinoid variant syndrome, secondary hypertrophic osteoarthropathy/digital clubbing, erythema gyratum repens, malignant acanthosis nigricans, sign of Leser-Trélat, tripe palms, hypertrichosis lanuginosa, acrokeratosis paraneoplastica, and dermatomyositis.

Keywords: Acrokeratosis paraneoplastica; Bronchial carcinoid variant syndrome; Ectopic ACTH syndrome; Hypertrophic osteoarthropathy; Lung cancer.

Publication types

  • Review

MeSH terms

  • ACTH Syndrome, Ectopic / pathology
  • Acanthosis Nigricans / etiology
  • Acanthosis Nigricans / pathology
  • Dermatomyositis / etiology
  • Dermatomyositis / pathology
  • Erythema / etiology
  • Erythema / pathology
  • Humans
  • Hypertrichosis / etiology
  • Hypertrichosis / pathology
  • Lung Neoplasms / complications
  • Lung Neoplasms / metabolism
  • Lung Neoplasms / pathology*
  • Osteoarthropathy, Secondary Hypertrophic / etiology
  • Osteoarthropathy, Secondary Hypertrophic / pathology
  • Paraneoplastic Syndromes / etiology
  • Paraneoplastic Syndromes / pathology
  • Superior Vena Cava Syndrome / etiology
  • Superior Vena Cava Syndrome / pathology