CSF and plasma adipokines after tonic-clonic seizures

Seizure. 2016 Jul:39:10-12. doi: 10.1016/j.seizure.2016.04.010. Epub 2016 May 4.


Purpose: Adipokines, especially leptin and adiponectin, have gained increasing importance in pathophysiology of various neurological diseases including epilepsy. There are experimental data suggesting a role for leptin in the genesis of seizures and neuroprotection related to seizures. However there are no clinical studies on the effects of epileptic seizures on adipokines.

Methods: We measured cerebrospinal fluid (CSF) and plasma levels of leptin, adiponectin and adipsin after provoked or unprovoked primary or secondarily generalized tonic-clonic seizures in 13 female patients and seven controls. The samples were taken within 24h after the seizure onset.

Results: Leptin plasma levels correlated negatively with the time to sample withdrawal, i.e. the longer the time interval between the seizure and the sample the lower the leptin levels in the patients. Interestingly, plasma adiponectin levels were significantly increased after the seizure episode.

Conclusion: This study provides further evidence that there are seizure-induced acute changes in adipokine metabolism. Leptin concentrations seem to decrease during the first 24h after the seizure whereas adiponectin levels increase. The meaning of this response is far from clear, but it might be an endogenous attempt to prevent harmful effects of epileptic seizures in the central nervous system.

Keywords: Adiponectin; Cerebrospinal fluid; Epilepsy; Leptin; Plasma; Tonic–clonic seizure.

MeSH terms

  • Adiponectin / blood
  • Adiponectin / cerebrospinal fluid
  • Adiponectin / metabolism*
  • Adolescent
  • Adult
  • Aged
  • Complement Factor D / cerebrospinal fluid
  • Complement Factor D / metabolism*
  • Epilepsy, Tonic-Clonic / blood
  • Epilepsy, Tonic-Clonic / cerebrospinal fluid
  • Epilepsy, Tonic-Clonic / metabolism*
  • Female
  • Humans
  • Leptin / blood
  • Leptin / cerebrospinal fluid
  • Leptin / metabolism*
  • Middle Aged
  • Young Adult


  • Adiponectin
  • Leptin
  • Complement Factor D