The Dual Complexity of PTX3 in Health and Disease: A Balancing Act?

Trends Mol Med. 2016 Jun;22(6):497-510. doi: 10.1016/j.molmed.2016.04.007. Epub 2016 May 11.


The humoral arm of innate immunity is complex and includes various molecules that serve as markers of inflammation with complementary characteristics, such as the short pentraxins C-reactive protein (CRP) and serum amyloid P (SAP) and the long pentraxin PTX3. There is a growing amount of evidence - including mouse and human genetics - that suggests that PTX3 is essential in conferring host resistance against selected pathogens and, moreover, that it plays a dual antagonistic role in the regulation of inflammation. Dissection of such a yin-and-yang role of pentraxins in immunity and inflammation is timely and significant as it may pave the way for better clinical exploitation against various diseases.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Binding Sites
  • C-Reactive Protein / genetics
  • C-Reactive Protein / immunology
  • C-Reactive Protein / metabolism*
  • Cell Line
  • Gene Expression
  • Humans
  • Immunity, Innate / immunology*
  • Inflammation / immunology*
  • Mutation
  • Neoplasms / genetics
  • Neoplasms / immunology
  • Neoplasms / metabolism
  • Serum Amyloid P-Component / genetics
  • Serum Amyloid P-Component / immunology
  • Serum Amyloid P-Component / metabolism*
  • Virus Diseases / immunology
  • Virus Diseases / metabolism


  • Serum Amyloid P-Component
  • PTX3 protein
  • C-Reactive Protein