Anti-herpesviral effects of a novel broad range anti-microbial quaternary ammonium silane, K21

Antiviral Res. 2016 Jul:131:166-73. doi: 10.1016/j.antiviral.2016.05.004. Epub 2016 May 12.

Abstract

We have created a novel quaternary ammonium silane, K21 through sol-gel chemistry, using an ethoxylated version of an organosilane quaternary ammonium compound and TetraEthyl Ortho Silicate (TEOS) as precursors. Previous studies using the precursor molecule quaternary ammonium compounds (QACs) and a methacryloxy version of K21, primarily designed for use in dental healthcare, have shown inhibited growth properties against several types of gram-positive and gram-negative bacteria including Escherichia coli, Streptococcus mutans, Actinomyces naeslundii and Candida albicans etc. Here we tested the effect of K21 on HSV-1, HHV-6A and HHV-7 in in vitro cell culture infection models. Our results show growth inhibitory effect of K21 on HSV-1, HHV-6A and HHV-7 infection.

Keywords: Anti-viral; HHV-6; HHV-7; HSV-1; QAC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Herpesvirus 1, Human / drug effects*
  • Herpesvirus 1, Human / growth & development
  • Herpesvirus 6, Human / drug effects*
  • Herpesvirus 6, Human / growth & development
  • Herpesvirus 7, Human / drug effects*
  • Herpesvirus 7, Human / growth & development
  • Quaternary Ammonium Compounds / chemistry
  • Quaternary Ammonium Compounds / pharmacology*
  • Silanes / chemistry
  • Silanes / pharmacology*

Substances

  • Antiviral Agents
  • K21 compound
  • Quaternary Ammonium Compounds
  • Silanes