Genomic Regions Associated with Sheep Resistance to Gastrointestinal Nematodes

Trends Parasitol. 2016 Jun;32(6):470-480. doi: 10.1016/ Epub 2016 May 13.


Genetic markers for sheep resistance to gastrointestinal parasites have long been sought by the livestock industry as a way to select more resistant individuals and to help farmers reduce parasite transmission by identifying and removing high egg shedders from the flock. Polymorphisms related to the major histocompatibility complex and interferon (IFN)-γ genes have been the most frequently reported markers associated with infection. Recently, a new picture is emerging from genome-wide studies, showing that not only immune mechanisms are important determinants of host resistance but that gastrointestinal mucus production and hemostasis pathways may also play a role.

Publication types

  • Review

MeSH terms

  • Animals
  • Breeding
  • Disease Resistance / genetics*
  • Genetic Markers / genetics
  • Genome / genetics*
  • Host-Parasite Interactions / genetics*
  • Intestinal Diseases, Parasitic / genetics
  • Intestinal Diseases, Parasitic / veterinary*
  • Nematoda / physiology
  • Nematode Infections / genetics
  • Nematode Infections / veterinary*
  • Sheep / genetics
  • Sheep Diseases / genetics*


  • Genetic Markers