Palladium-Catalyzed Carboxylation of Activated Vinylcyclopropanes with CO2

Org Lett. 2016 Jun 3;18(11):2754-7. doi: 10.1021/acs.orglett.6b01231. Epub 2016 May 17.

Abstract

By using a palladium catalyst with ZnEt2, activated vinylcyclopropanes were successfully converted into the corresponding β,γ-unsaturated carboxylic acids in high yields under a CO2 atmosphere (1 atm). The intermediate in this reaction is thought to be a nucleophilic η(1)-allylethylpalladium species, which would be produced from π-allylpalladium and ZnEt2 (umpolung reactivity).

Publication types

  • Research Support, Non-U.S. Gov't