Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 May 23;26(10):1274-84.
doi: 10.1016/j.cub.2016.03.053. Epub 2016 May 12.

A Eukaryote Without a Mitochondrial Organelle

Affiliations

A Eukaryote Without a Mitochondrial Organelle

Anna Karnkowska et al. Curr Biol. .

Abstract

The presence of mitochondria and related organelles in every studied eukaryote supports the view that mitochondria are essential cellular components. Here, we report the genome sequence of a microbial eukaryote, the oxymonad Monocercomonoides sp., which revealed that this organism lacks all hallmark mitochondrial proteins. Crucially, the mitochondrial iron-sulfur cluster assembly pathway, thought to be conserved in virtually all eukaryotic cells, has been replaced by a cytosolic sulfur mobilization system (SUF) acquired by lateral gene transfer from bacteria. In the context of eukaryotic phylogeny, our data suggest that Monocercomonoides is not primitively amitochondrial but has lost the mitochondrion secondarily. This is the first example of a eukaryote lacking any form of a mitochondrion, demonstrating that this organelle is not absolutely essential for the viability of a eukaryotic cell.

Comment in

Similar articles

See all similar articles

Cited by 68 articles

See all "Cited by" articles

Publication types

Grant support

LinkOut - more resources

Feedback