How Mesp1 makes a move

J Cell Biol. 2016 May 23;213(4):411-3. doi: 10.1083/jcb.201604121. Epub 2016 May 16.

Abstract

The transcription factors Mesp1 and Mesp2 have essential roles in the migration and specification of multipotent progenitor cells at the onset of cardiogenesis. Chiapparo et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201505082) identify common Mesp functions in fate specification and Mesp1-specific targets controlling the speed and direction of progenitor cell migration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Basic Helix-Loop-Helix Proteins / metabolism*
  • Cell Differentiation / physiology
  • Cell Movement / physiology
  • Gene Expression Regulation, Developmental / physiology
  • Heart / growth & development*
  • Humans
  • Mesoderm / metabolism
  • Mesoderm / physiology
  • Pluripotent Stem Cells / metabolism
  • Pluripotent Stem Cells / physiology
  • Stem Cells / metabolism*
  • Stem Cells / physiology*

Substances

  • Basic Helix-Loop-Helix Proteins