Neuroprotective effect of lidocaine: is there clinical potential?

Int J Physiol Pathophysiol Pharmacol. 2016 Apr 25;8(1):9-13. eCollection 2016.


Local anesthetic lidocaine has been shown to be protective in animal models of focal and global ischemia as well as in in vitro hypoxic models. Lidocaine has been tested in patients for its potential protective effect on postoperative cognitive dysfunction. This mini-review summarizes the laboratory and clinical evidences and discusses its clinical applications as neuroprotective agent.

Keywords: Lidocaine; neuroprotection; postoperative cognitive dysfunction; stroke.

Publication types

  • Review