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Review
. 2016 May 12;17(5):716.
doi: 10.3390/ijms17050716.

MicroRNA in United Airway Diseases

Zheng Liu  1 , Xin-Hao Zhang  2 , Borja Callejas-Díaz  3 , Joaquim Mullol  4
Affiliations
Review

MicroRNA in United Airway Diseases

Zheng Liu et al. Int J Mol Sci. .

Abstract

The concept of united airway diseases (UAD) has received increasing attention in recent years. Sustained and increased inflammation is a common feature of UAD, which is inevitably accompanied with marked gene modification and tight gene regulation. However, gene regulation in the common inflammatory processes in UAD remains unclear. MicroRNA (miRNA), a novel regulator of gene expression, has been considered to be involved in many inflammatory diseases. Although there are an increasing number of studies of miRNAs in inflammatory upper and lower airway diseases, few miRNAs have been identified that directly link the upper and lower airways. In this article, therefore, we reviewed the relevant studies available in order to improve the understanding of the roles of miRNAs in the interaction and pathogenesis of UAD.

Keywords: allergic rhinitis; asthma; inflammation; microRNA; rhinosinusitis; united airways disease.

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Figures

Figure 1
Figure 1
A summary of miRNAs potentially involved in the common pathways in allergic rhinitis and asthma. Effects of induction or stimulation (black arrows), repression or inhibition (T arrows) or indirect repression or inhibition (question mark) are shown.
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