Brazilian Green Propolis Improves Antioxidant Function in Patients with Type 2 Diabetes Mellitus

Int J Environ Res Public Health. 2016 May 13;13(5):498. doi: 10.3390/ijerph13050498.

Abstract

Propolis contains a variety of bioactive components and possesses many biological properties. This study was designed to evaluate potential effects of Brazilian green propolis on glucose metabolism and antioxidant function in patients with type 2 diabetes mellitus (T2DM). In the 18-week randomized controlled study, enrolled patients with T2DM were randomly assigned to Brazilian green propolis group (900 mg/day) (n = 32) and control group (n = 33). At the end of the study, no significant difference was found in serum glucose, glycosylated hemoglobin, insulin, aldose reductase or adiponectin between the two groups. However, serum GSH and total polyphenols were significantly increased, and serum carbonyls and lactate dehydrogenase activity were significantly reduced in the Brazilian green propolis group. Serum TNF-α was significantly decreased, whereas serum IL-1β and IL-6 were significantly increased in the Brazilian green propolis group. It is concluded that Brazilian green propolis is effective in improving antioxidant function in T2DM patients.

Keywords: Brazilian green propolis; antioxidant function; type 2 diabetes mellitus.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adiponectin / blood
  • Adult
  • Aged
  • Blood Glucose / analysis
  • Brazil
  • Cytokines / blood
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / drug therapy
  • Female
  • Glutathione / blood
  • Glycated Hemoglobin A / analysis
  • Humans
  • Insulin / blood
  • Male
  • Middle Aged
  • Polyphenols / blood
  • Propolis / pharmacology*
  • Propolis / therapeutic use

Substances

  • ADIPOQ protein, human
  • Adiponectin
  • Blood Glucose
  • Cytokines
  • Glycated Hemoglobin A
  • Insulin
  • Polyphenols
  • Propolis
  • Glutathione